A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole

BACKGROUND: Aromatase (CYP19A1) regulates estrogen biosynthesis. Polymorphisms in CYP19A1 have been related to the pathogenesis of breast cancer (BC). Inhibition of aromatase with letrozole constitutes the best option for treating estrogen-dependent BC in postmenopausal women. We evaluate a series o...

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Main Authors: Garcia-Casado, Zaida, Guerrero-Zotano, Angel, Llombart-Cussac, Antonio, Calatrava, Ana, Fernandez-Serra, Antonio, Ruiz-Simon, Amparo, Gavila, Joaquin, Climent, Miguel A, Almenar, Sergio, Cervera-Deval, Jose, Campos, Josefina, Albaladejo, Carlos Vazquez, Llombart-Bosch, Antonio, Guillem, Vicente, Lopez-Guerrero, Jose A
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830181/
https://ncbi.nlm.nih.gov/pubmed/20144226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-36
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