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Sensitivity to aromatase inhibitor letrozole is prolonged after a “break” in treatment
Using a hormone dependent xenograft model, we established that loss of response to letrozole was accompanied by up-regulation of Her-2/MAPK pathway and downregulation of ERα and aromatase activity. In our previous study, we showed that stopping letrozole treatment or adding trastuzumab could reverse...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831468/ https://ncbi.nlm.nih.gov/pubmed/20053764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0696 |
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