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Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen

In this study we investigated adaptive mechanisms associated with aromatase inhibitor (AI) resistance in breast cancer cells and show that sensitivity to AIs can be extended through dual inhibition of Estrogen Receptor (ER) and Human Epidermal Receptor-2 (Her-2) signaling. We utilized human ER-posit...

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Detalhes bibliográficos
Main Authors: Sabnis, Gauri, Schayowitz, Adam, Goloubeva, Olga, Macedo, Luciana, Brodie, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644349/
https://ncbi.nlm.nih.gov/pubmed/19190349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0857
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