Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen

In this study we investigated adaptive mechanisms associated with aromatase inhibitor (AI) resistance in breast cancer cells and show that sensitivity to AIs can be extended through dual inhibition of Estrogen Receptor (ER) and Human Epidermal Receptor-2 (Her-2) signaling. We utilized human ER-posit...

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Bibliographic Details
Main Authors: Sabnis, Gauri, Schayowitz, Adam, Goloubeva, Olga, Macedo, Luciana, Brodie, Angela
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644349/
https://ncbi.nlm.nih.gov/pubmed/19190349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0857
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