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Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen
In this study we investigated adaptive mechanisms associated with aromatase inhibitor (AI) resistance in breast cancer cells and show that sensitivity to AIs can be extended through dual inhibition of Estrogen Receptor (ER) and Human Epidermal Receptor-2 (Her-2) signaling. We utilized human ER-posit...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644349/ https://ncbi.nlm.nih.gov/pubmed/19190349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0857 |
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