Human papillomavirus regulates HER3 expression in head and neck cancer: implications for targeted HER3 therapy in HPV(+) patients

PURPOSE: Human papillomavirus (HPV) 16 plays an etiologic role in a growing subset of HNSCCs, where viral expression of the E6 and E7 oncoproteins are necessary for tumor growth and maintenance. Although patients with HPV(+) tumors have a more favorable prognosis, there are currently no HPV-selectiv...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Brand, Toni M., Hartmann, Stefan, Bhola, Neil E., Peyser, Noah D., Li, Hua, Zeng, Yan, Wechsler, Erin Isaacson, Ranall, Max V., Bandyopadhyay, Sourav, Duvvuri, Umamaheswar, LaVallee, Theresa M., Jordan, Richard C.K., Johnson, Daniel E., Grandis, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474133/
https://ncbi.nlm.nih.gov/pubmed/27986750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2203
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