HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma

BYL719 is a PI3K inhibitor that has demonstrated efficacy in the treatment of head and neck squamous cell carcinoma. BYL719 exerts its therapeutic effect by suppressing AKT and other proliferative signaling mechanisms. Despite PI3K inhibition and AKT suppression, residual activity of protein S6, a c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Meister, Kara S., Godse, Neal R., Khan, Nayel I., Hedberg, Matthew L., Kemp, Carolyn, Kulkarni, Sucheta, Alvarado, Diego, LaVallee, Theresa, Kim, Seungwon, Grandis, Jennifer R., Duvvuri, Umamaheswar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591241/
https://ncbi.nlm.nih.gov/pubmed/31235758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45589-y
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