HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma

BYL719 is a PI3K inhibitor that has demonstrated efficacy in the treatment of head and neck squamous cell carcinoma. BYL719 exerts its therapeutic effect by suppressing AKT and other proliferative signaling mechanisms. Despite PI3K inhibition and AKT suppression, residual activity of protein S6, a c...

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Pubblicato in:Sci Rep
Autori principali: Meister, Kara S., Godse, Neal R., Khan, Nayel I., Hedberg, Matthew L., Kemp, Carolyn, Kulkarni, Sucheta, Alvarado, Diego, LaVallee, Theresa, Kim, Seungwon, Grandis, Jennifer R., Duvvuri, Umamaheswar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591241/
https://ncbi.nlm.nih.gov/pubmed/31235758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45589-y
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