Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K) have been shown to transform human mammary epithelial cells (MECs). These mutations are present in all breast cancer subtypes, including basal-like breast cancer (BLBC). Using liquid chromatography...

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Publicado no:Mol Cell Proteomics
Main Authors: Young, Christian D., Zimmerman, Lisa J., Hoshino, Daisuke, Formisano, Luigi, Hanker, Ariella B., Gatza, Michael L., Morrison, Meghan M., Moore, Preston D., Whitwell, Corbin A., Dave, Bhuvanesh, Stricker, Thomas, Bhola, Neil E., Silva, Grace O., Patel, Premal, Brantley-Sieders, Dana M., Levin, Maren, Horiates, Marina, Palma, Norma A., Wang, Kai, Stephens, Philip J., Perou, Charles M., Weaver, Alissa M., O'Shaughnessy, Joyce A., Chang, Jenny C., Park, Ben Ho, Liebler, Daniel C., Cook, Rebecca S., Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587316/
https://ncbi.nlm.nih.gov/pubmed/25953087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.049783
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