Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K) have been shown to transform human mammary epithelial cells (MECs). These mutations are present in all breast cancer subtypes, including basal-like breast cancer (BLBC). Using liquid chromatography...

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Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Young, Christian D., Zimmerman, Lisa J., Hoshino, Daisuke, Formisano, Luigi, Hanker, Ariella B., Gatza, Michael L., Morrison, Meghan M., Moore, Preston D., Whitwell, Corbin A., Dave, Bhuvanesh, Stricker, Thomas, Bhola, Neil E., Silva, Grace O., Patel, Premal, Brantley-Sieders, Dana M., Levin, Maren, Horiates, Marina, Palma, Norma A., Wang, Kai, Stephens, Philip J., Perou, Charles M., Weaver, Alissa M., O'Shaughnessy, Joyce A., Chang, Jenny C., Park, Ben Ho, Liebler, Daniel C., Cook, Rebecca S., Arteaga, Carlos L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587316/
https://ncbi.nlm.nih.gov/pubmed/25953087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.049783
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