Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer

Basal-like breast cancer (BLBC) is an aggressive disease that lacks a clinically-approved targeting therapy. Traditional chemotherapy is effective in BLBC, but it spares the cancer stem cell (CSC)-like population which is likely to contribute to cancer recurrence after the initial treatment. DUSP4 i...

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Main Authors: Balko, Justin M., Schwarz, Luis J., Bhola, Neil E., Kurupi, Richard, Owens, Phillip, Miller, Todd W., Gómez, Henry, Cook, Rebecca S., Arteaga, Carlos L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090144/
https://ncbi.nlm.nih.gov/pubmed/23966295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1385
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