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Honokiol inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors

PURPOSE: To investigate the utility of honokiol, a naturally-occurring compound, in the treatment of head and neck squamous cell carcinoma (HNSCC) as well as its ability to target the epidermal growth factor receptor (EGFR), a critical therapeutic target in HNSCC, and to enhance the effects of other...

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Hlavní autoři: Leeman-Neill, Rebecca J., Cai, Quan, Joyce, Sonali C., Thomas, Sufi M., Bhola, Neil E., Neill, Daniel B., Arbiser, Jack L., Grandis, Jennifer R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871379/
https://ncbi.nlm.nih.gov/pubmed/20388852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0333
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