Targeting TORC1/2 Enhances Sensitivity to EGFR Inhibitors in Head and Neck Cancer Preclinical Models

le Cassell, Andre, Freilino, Maria L, Lee, Jessica, Barr, Sharon, Wang, Lin, Panahandeh, Mary C, Thomas, Sufi M, Grandis, Jennifer R
Foilsithe 2012

Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors*

le Altman, Jessica K., Sassano, Antonella, Kaur, Surinder, Glaser, Heather, Kroczynska, Barbara, Redig, Amanda J., Russo, Suzanne, Barr, Sharon, Platanias, Leonidas C.
Foilsithe 2011

Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors

le Falcon, Beverly L., Barr, Sharon, Gokhale, Prafulla C., Chou, Jeyling, Fogarty, Jennifer, Depeille, Philippe, Miglarese, Mark, Epstein, David M., McDonald, Donald M.
Foilsithe 2011

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

le Carayol, Nathalie, Vakana, Eliza, Sassano, Antonella, Kaur, Surinder, Goussetis, Dennis J., Glaser, Heather, Druker, Brian J., Donato, Nicholas J., Altman, Jessica K., Barr, Sharon, Platanias, Leonidas C.
Foilsithe 2010

Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions

le Barr, Sharon, Thomson, Stuart, Buck, Elizabeth, Russo, Suzanne, Petti, Filippo, Sujka-Kwok, Izabela, Eyzaguirre, Alexandra, Rosenfeld-Franklin, Maryland, Gibson, Neil W., Miglarese, Mark, Epstein, David, Iwata, Kenneth K., Haley, John D.
Foilsithe 2008

A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies

le Mateo, Joaquin, Olmos, David, Dumez, Herlinde, Poondru, Srinivasu, Samberg, Nancy L, Barr, Sharon, Van Tornout, Jan M, Jie, Fei, Sandhu, Shahneen, Tan, Daniel S, Moreno, Victor, LoRusso, Patricia M, Kaye, Stan B, Schöffski, Patrick
Foilsithe in Br J Cancer (2016)

An ensemble approach to accurately detect somatic mutations using SomaticSeq

le Fang, Li Tai, Afshar, Pegah Tootoonchi, Chhibber, Aparna, Mohiyuddin, Marghoob, Fan, Yu, Mu, John C., Gibeling, Greg, Barr, Sharon, Asadi, Narges Bani, Gerstein, Mark B., Koboldt, Daniel C., Wang, Wenyi, Wong, Wing H., Lam, Hugo YK
Foilsithe in Genome Biol (2015)

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

le Gupta, Mamta, Hendrickson, Andrea E. Wahner, Yun, Seong Seok, Han, Jing Jing, Schneider, Paula A., Koh, Brian D., Stenson, Mary J., Wellik, Linda E., Shing, Jennifer C., Peterson, Kevin L., Flatten, Karen S., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Barr, Sharon, Witzig, Thomas E., Kaufmann, Scott H.
Foilsithe 2012