Targeting TORC1/2 Enhances Sensitivity to EGFR Inhibitors in Head and Neck Cancer Preclinical Models

Head and neck squamous cell carcinoma (HNSCC) is characterized by overexpression of the epidermal growth factor receptor (EGFR) where treatments targeting EGFR have met with limited clinical success. Elucidation of the key downstream-pathways that remain activated in the setting of EGFR blockade may...

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Bibliographic Details
Main Authors: Cassell, Andre, Freilino, Maria L, Lee, Jessica, Barr, Sharon, Wang, Lin, Panahandeh, Mary C, Thomas, Sufi M, Grandis, Jennifer R
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514742/
https://ncbi.nlm.nih.gov/pubmed/23226094
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