Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors*

PURPOSE: To determine whether mTORC2 and RI-mTORC1 complexes are present in AML cells and to examine the effects of dual mTORC2/mTORC1 inhibition on primitive AML leukemic progenitors. EXPERIMENTAL DESIGN: Combinations of different experimental approaches were used, including immunoblotting to detec...

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Detalhes bibliográficos
Main Authors: Altman, Jessica K., Sassano, Antonella, Kaur, Surinder, Glaser, Heather, Kroczynska, Barbara, Redig, Amanda J., Russo, Suzanne, Barr, Sharon, Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131493/
https://ncbi.nlm.nih.gov/pubmed/21415215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2285
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