Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

mTOR-generated signals play critical roles in growth of leukemic cells by controlling mRNA translation of genes that promote mitogenic responses. Despite extensive work on the functional relevance of rapamycin-sensitive mTORC1 complexes, much less is known on the roles of rapamycin-insensitive (RI)...

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Detalhes bibliográficos
Main Authors: Carayol, Nathalie, Vakana, Eliza, Sassano, Antonella, Kaur, Surinder, Goussetis, Dennis J., Glaser, Heather, Druker, Brian J., Donato, Nicholas J., Altman, Jessica K., Barr, Sharon, Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906574/
https://ncbi.nlm.nih.gov/pubmed/20616057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005114107
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