Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

mTOR-generated signals play critical roles in growth of leukemic cells by controlling mRNA translation of genes that promote mitogenic responses. Despite extensive work on the functional relevance of rapamycin-sensitive mTORC1 complexes, much less is known on the roles of rapamycin-insensitive (RI)...

Full description

Saved in:
Bibliographic Details
Main Authors: Carayol, Nathalie, Vakana, Eliza, Sassano, Antonella, Kaur, Surinder, Goussetis, Dennis J., Glaser, Heather, Druker, Brian J., Donato, Nicholas J., Altman, Jessica K., Barr, Sharon, Platanias, Leonidas C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906574/
https://ncbi.nlm.nih.gov/pubmed/20616057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005114107
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items