Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers

Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma (HNSCC)(1, 2). Identification of mutations that predict therapeutic response would be a major advance. We determined the mutationally altered, targetable mitogenic pathways in a large HNSCC cohort. Analysis of who...

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Detalhes bibliográficos
Main Authors: Lui, Vivian Wai Yan, Hedberg, Matthew L., Li, Hua, Vangara, Bhavana S., Pendleton, Kelsey, Zeng, Yan, Lu, Yiling, Zhang, Qiuhong, Du, Yu, Gilbert, Breean, Freilino, Maria, Sauerwein, Sam, Peyser, Noah, Xiao, Dong, Diergaarde, Brenda, Wang, Lin, Chiosea, Simion, Seethala, Raja, Johnson, Jonas T., Kim, Seungwon, Duvvuri, Umamaheswar, Ferris, Robert L., Romkes, Marjorie, Nukui, Tomoko, Ng, Patrick Kwok-Shing, Garraway, Levi A., Hammerman, Peter S., Mills, Gordon B., Grandis, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710532/
https://ncbi.nlm.nih.gov/pubmed/23619167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0103
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