Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers

Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma (HNSCC)(1, 2). Identification of mutations that predict therapeutic response would be a major advance. We determined the mutationally altered, targetable mitogenic pathways in a large HNSCC cohort. Analysis of who...

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Autores principales: Lui, Vivian Wai Yan, Hedberg, Matthew L., Li, Hua, Vangara, Bhavana S., Pendleton, Kelsey, Zeng, Yan, Lu, Yiling, Zhang, Qiuhong, Du, Yu, Gilbert, Breean, Freilino, Maria, Sauerwein, Sam, Peyser, Noah, Xiao, Dong, Diergaarde, Brenda, Wang, Lin, Chiosea, Simion, Seethala, Raja, Johnson, Jonas T., Kim, Seungwon, Duvvuri, Umamaheswar, Ferris, Robert L., Romkes, Marjorie, Nukui, Tomoko, Ng, Patrick Kwok-Shing, Garraway, Levi A., Hammerman, Peter S., Mills, Gordon B., Grandis, Jennifer R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710532/
https://ncbi.nlm.nih.gov/pubmed/23619167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0103
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