Calmodulin kinase II accelerates L-type Ca(2+) current recovery from inactivation and compensates for the direct inhibitory effect of [Ca(2+)](i) in rat ventricular myocytes

Por Guo, Jiqing, Duff, Henry J
Publicado em 2006

Rehabilitating drug-induced long-QT promoters: In-silico design of hERG-neutral cisapride analogues with retained pharmacological activity

Por Durdagi, Serdar, Randall, Trevor, Duff, Henry J, Chamberlin, Adam, Noskov, Sergei Y
Publicado em 2014

­Using the C. elegans lem-2 Gene to Reconstruct the Human LEMD2 Mutation Associated with Hutterite-type Cataract/Cardiomyopathy

Por AlKhaleefa, Ayaa, Snider, Frances L., Duff, Henry J., McGhee, James D.
Publicado no MicroPubl Biol (2020)

Refinement of a cryo-EM structure of hERG: Bridging structure and function

Por Khan, Hanif M., Guo, Jiqing, Duff, Henry J., Tieleman, D. Peter, Noskov, Sergei Y.
Publicado no Biophys J (2021)

In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave

Por Liu, Gang, Iden, Jason B, Kovithavongs, Kay, Gulamhusein, Rashida, Duff, Henry J, Kavanagh, Katherine M
Publicado em 2004

Caffeine Induces Ca(2+) Release by Reducing The Threshold for Luminal Ca(2+) Activation of the Ryanodine Receptor

Por Kong, Huihui, Jones, Peter P., Koop, Andrea, Zhang, Lin, Duff, Henry J., Wayne Chen, S. R.
Publicado em 2008

Mechanism of hypotensive transients associated with abrupt bradycardias in conscious rabbits

Por Sheldon, Robert S, Wright, Christopher I, Duff, Henry J, Thakore, Ela, Gillis, Anne M, Roach, Daniel E
Publicado em 2007

Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes

Por Shafa, Mehdi, Krawetz, Roman, Zhang, Yuan, Rattner, Jerome B, Godollei, Anna, Duff, Henry J, Rancourt, Derrick E
Publicado em 2011

Blockade of HERG cardiac K(+) current by antifungal drug miconazole

Por Kikuchi, Kan, Nagatomo, Toshihisa, Abe, Haruhiko, Kawakami, Kazunobu, Duff, Henry J, Makielski, Jonathan C, January, Craig T, Nakashima, Yasuhide
Publicado em 2004

Skeletal and Cardiac Ryanodine Receptors Exhibit Different Responses to Ca(2+) Overload and Luminal Ca(2+)

Por Kong, Huihui, Wang, Ruiwu, Chen, Wenqian, Zhang, Lin, Chen, Keyun, Shimoni, Yakhin, Duff, Henry J., Chen, S. R. Wayne
Publicado em 2007

Effect of stimulation rate, sarcomere length and Ca(2+) on force generation by mouse cardiac muscle

Por Stuyvers, Bruno D, McCulloch, Andrew D, Guo, Jiqing, Duff, Henry J, ter Keurs, Henk E D J
Publicado em 2002

Interactions of H562 in the S5 Helix with T618 and S621 in the Pore Helix Are Important Determinants of hERG1 Potassium Channel Structure and Function

Por Lees-Miller, James P., Subbotina, Julia O., Guo, Jiqing, Yarov-Yarovoy, Vladimir, Noskov, Sergei Y., Duff, Henry J.
Publicado em 2009

Structural Refinement of the hERG1 Pore and Voltage-Sensing Domains with ROSETTA-Membrane and Molecular Dynamics Simulations

Por Subbotina, Julia, Yarov-Yarovoy, Vladimir, Lees-Miller, James, Durdagi, Serdar, Guo, Jiqing, Duff, Henry J., Noskov, Sergei Yu.
Publicado em 2010

Phenotypic Analysis of Arrhythmogenic Cardiomyopathy in the Hutterite Population: Role of Electrocardiogram in Identifying High‐Risk Desmocollin‐2 Carriers

Por Wong, Jorge A., Duff, Henry J., Yuen, Tiffany, Kolman, Louis, Exner, Derek V., Weeks, Sarah G., Gerull, Brenda
Publicado no J Am Heart Assoc (2014)

Kinetic Model for NS1643 Drug Activation of WT and L529I Variants of Kv11.1 (hERG1) Potassium Channel

Por Perissinotti, Laura L., Guo, Jiqing, De Biase, Pablo M., Clancy, Colleen E., Duff, Henry J., Noskov, Sergei Y.
Publicado no Biophys J (2015)

Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade

Por Kudaibergenova, Meruyert, Guo, Jiqing, Khan, Hanif M., Zahid, Farhan, Lees-Miller, James, Noskov, Sergei Yu., Duff, Henry J.
Publicado no Front Pharmacol (2020)

Selective Knockout of Mouse ERG1 B Potassium Channel Eliminates I(Kr) in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia

Por Lees-Miller, James P., Guo, Jiqing, Somers, Julie R., Roach, Dan E., Sheldon, Robert S., Rancourt, Derrick E., Duff, Henry J.
Publicado em 2003

Role of the pH in state-dependent blockade of hERG currents

Por Wang, Yibo, Guo, Jiqing, Perissinotti, Laura L., Lees-Miller, James, Teng, Guoqi, Durdagi, Serdar, Duff, Henry J., Noskov, Sergei Yu.
Publicado no Sci Rep (2016)

Selectivity filter modalities and rapid inactivation of the hERG1 channel

Por Miranda, Williams E., DeMarco, Kevin R., Guo, Jiqing, Duff, Henry J., Vorobyov, Igor, Clancy, Colleen E., Noskov, Sergei Yu.
Publicado no Proc Natl Acad Sci U S A (2020)

Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators

Por Guo, Jiqing, Durdagi, Serdar, Changalov, Mohamed, Perissinotti, Laura L., Hargreaves, Jason M., Back, Thomas G., Noskov, Sergei Y., Duff, Henry J.
Publicado em 2014