Interactions of H562 in the S5 Helix with T618 and S621 in the Pore Helix Are Important Determinants of hERG1 Potassium Channel Structure and Function

hERG1 is a member of the cyclic nucleotide binding domain family of K(+) channels. Alignment of cyclic nucleotide binding domain channels revealed an evolutionary conserved sequence HwX(A/G)C in the S5 domain. We reasoned that histidine 562 in hERG1 could play an important structure-function role. T...

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Autori principali: Lees-Miller, James P., Subbotina, Julia O., Guo, Jiqing, Yarov-Yarovoy, Vladimir, Noskov, Sergei Y., Duff, Henry J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2009
Soggetti:
Channels, Receptors, and Electrical Signaling
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711401/
https://ncbi.nlm.nih.gov/pubmed/19413965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.01.028
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