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Structural Refinement of the hERG1 Pore and Voltage-Sensing Domains with ROSETTA-Membrane and Molecular Dynamics Simulations
The hERG1 gene (Kv11.1) encodes a voltage-gated potassium channel. Mutations in this gene, lead to one form of the Long QT Syndrome in humans (LQTS). Promiscuous binding of drugs to hERG1 is known to alter the structure/function of the channel leading to an acquired form of the LQTS. Expectably, cre...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939218/ https://ncbi.nlm.nih.gov/pubmed/20740484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22815 |
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