Role of the pH in state-dependent blockade of hERG currents

Mutations that reduce inactivation of the voltage-gated Kv11.1 potassium channel (hERG) reduce binding for a number of blockers. State specific block of the inactivated state of hERG block may increase risks of drug-induced Torsade de pointes. In this study, molecular simulations of dofetilide bindi...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Wang, Yibo, Guo, Jiqing, Perissinotti, Laura L., Lees-Miller, James, Teng, Guoqi, Durdagi, Serdar, Duff, Henry J., Noskov, Sergei Yu.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059635/
https://ncbi.nlm.nih.gov/pubmed/27731415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32536
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