Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators

One of the main culprits in modern drug discovery is apparent cardiotoxicity of many lead-candidates via inadvertent pharmacologic blockade of K(+), Ca(2+) and Na(+) currents. Many drugs inadvertently block hERG1 leading to an acquired form of the Long QT syndrome and potentially lethal polymorphic...

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Main Authors: Guo, Jiqing, Durdagi, Serdar, Changalov, Mohamed, Perissinotti, Laura L., Hargreaves, Jason M., Back, Thomas G., Noskov, Sergei Y., Duff, Henry J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156305/
https://ncbi.nlm.nih.gov/pubmed/25191697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105553
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