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Selectivity filter modalities and rapid inactivation of the hERG1 channel
The human ether-á-go-go–related gene (hERG1) channel conducts small outward K(+) currents that are critical for cardiomyocyte membrane repolarization. The gain-of-function mutation N629D at the outer mouth of the selectivity filter (SF) disrupts inactivation and K(+)-selective transport in hERG1, le...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7022143/ https://ncbi.nlm.nih.gov/pubmed/31980532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909196117 |
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