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Selectivity filter modalities and rapid inactivation of the hERG1 channel

The human ether-á-go-go–related gene (hERG1) channel conducts small outward K(+) currents that are critical for cardiomyocyte membrane repolarization. The gain-of-function mutation N629D at the outer mouth of the selectivity filter (SF) disrupts inactivation and K(+)-selective transport in hERG1, le...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Miranda, Williams E., DeMarco, Kevin R., Guo, Jiqing, Duff, Henry J., Vorobyov, Igor, Clancy, Colleen E., Noskov, Sergei Yu.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022143/
https://ncbi.nlm.nih.gov/pubmed/31980532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909196117
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