Harnessing AlphaFold to reveal hERG channel conformational state secrets
To design safe, selective, and effective new therapies, there must be a deep understanding of the structure and function of the drug target. One of the most difficult problems to solve has been the resolution of discrete conformational states of transmembrane ion channel proteins. An example is KV11...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications Ltd
2025-07-01
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| Serier: | eLife |
| Fag: | |
| Online adgang: | https://elifesciences.org/articles/104901 |
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