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Harnessing AlphaFold to reveal hERG channel conformational state secrets

To design safe, selective, and effective new therapies, there must be a deep understanding of the structure and function of the drug target. One of the most difficult problems to solve has been the resolution of discrete conformational states of transmembrane ion channel proteins. An example is KV11...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Khoa Ngo, Pei-Chi Yang, Vladimir Yarov-Yarovoy, Colleen E Clancy, Igor Vorobyov
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: eLife Sciences Publications Ltd 2025-07-01
Цуврал:eLife
Нөхцлүүд:
Онлайн хандалт:https://elifesciences.org/articles/104901
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