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Kinetic Model for NS1643 Drug Activation of WT and L529I Variants of Kv11.1 (hERG1) Potassium Channel
Congenital and acquired (drug-induced) forms of the human long-QT syndrome are associated with alterations in Kv11.1 (hERG) channel-controlled repolarizing I(Kr) currents of cardiac action potentials. A mandatory drug screen implemented by many countries led to a discovery of a large group of small...
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| Vydáno v: | Biophys J |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Biophysical Society
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375712/ https://ncbi.nlm.nih.gov/pubmed/25809254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.12.056 |
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