Kinetic Model for NS1643 Drug Activation of WT and L529I Variants of Kv11.1 (hERG1) Potassium Channel

Congenital and acquired (drug-induced) forms of the human long-QT syndrome are associated with alterations in Kv11.1 (hERG) channel-controlled repolarizing I(Kr) currents of cardiac action potentials. A mandatory drug screen implemented by many countries led to a discovery of a large group of small...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Perissinotti, Laura L., Guo, Jiqing, De Biase, Pablo M., Clancy, Colleen E., Duff, Henry J., Noskov, Sergei Y.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2015
Teme:
Channels and Transporters
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375712/
https://ncbi.nlm.nih.gov/pubmed/25809254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.12.056
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