Selective Knockout of Mouse ERG1 B Potassium Channel Eliminates I(Kr) in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia

The ERG1 gene encodes a family of potassium channels. Mutations in human ERG1 lead to defects in cardiac repolarization, referred to as the long QT syndrome. Through homologous recombination in mouse embryonic stem cells the ERG1 B potassium channel transcript was eliminated while the ERG1 A transcr...

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Detalhes bibliográficos
Main Authors: Lees-Miller, James P., Guo, Jiqing, Somers, Julie R., Roach, Dan E., Sheldon, Robert S., Rancourt, Derrick E., Duff, Henry J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149456/
https://ncbi.nlm.nih.gov/pubmed/12612061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.6.1856-1862.2003
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