Blockade of HERG cardiac K(+) current by antifungal drug miconazole

1. Miconazole, an imidazole antifungal agent, is associated with acquired long QT syndrome and ventricular arrhythmias. Miconazole increases the plasma concentration of QT-prolonging drugs by inhibiting the hepatic cytochrome P450 metabolic pathway, but whether it has direct effects on cardiac ion c...

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Detalhes bibliográficos
Main Authors: Kikuchi, Kan, Nagatomo, Toshihisa, Abe, Haruhiko, Kawakami, Kazunobu, Duff, Henry J, Makielski, Jonathan C, January, Craig T, Nakashima, Yasuhide
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576066/
https://ncbi.nlm.nih.gov/pubmed/15778703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706095
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