Comparison of HERG channel blocking effects of various β-blockers – implication for clinical strategy

1. β-Blockers are widely used in the treatment of cardiovascular diseases. However, their effects on HERG channels at comparable conditions remain to be defined. We investigated the direct acute effects of β-blockers on HERG current and the molecular basis of drug binding to HERG channels with mutat...

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Detalhes bibliográficos
Main Authors: Kawakami, Kazunobu, Nagatomo, Toshihisa, Abe, Haruhiko, Kikuchi, Kan, Takemasa, Hiroko, Anson, Blake D, Delisle, Brian P, January, Craig T, Nakashima, Yasuhide
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751343/
https://ncbi.nlm.nih.gov/pubmed/16314852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706508
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