Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes

Mutations in human ether-a-go-go-related gene 1 (hERG) are linked to long QT syndrome type 2 (LQT2). hERG encodes the pore-forming α-subunits that coassemble to form rapidly activating delayed rectifier K(+) current in the heart. LQT2-linked missense mutations have been extensively studied in noncar...

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Main Authors: Lin, Eric C., Holzem, Katherine M., Anson, Blake D., Moungey, Brooke M., Balijepalli, Sadguna Y., Tester, David J., Ackerman, Michael J., Delisle, Brian P., Balijepalli, Ravi C., January, Craig T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886621/
https://ncbi.nlm.nih.gov/pubmed/20363883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01236.2009
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