Small GTPase Determinants for the Golgi Processing and Plasmalemmal Expression of Human Ether-a-go-go Related (hERG) K(+) Channels

The pro-arrhythmic Long QT syndrome (LQT) is linked to 10 different genes (LQT1–10). Approximately 40% of genotype-positive LQT patients have LQT2, which is characterized by mutations in the human ether-a-go-go related gene (hERG). hERG encodes the voltage-gated K(+) channel α-subunits that form the...

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Autori principali: Delisle, Brian P., Underkofler, Heather A. S., Moungey, Brooke M., Slind, Jessica K., Kilby, Jennifer A., Best, Jabe M., Foell, Jason D., Balijepalli, Ravi C., Kamp, Timothy J., January, Craig T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Membrane Transport, Structure, Function, and Biogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631954/
https://ncbi.nlm.nih.gov/pubmed/19029296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807289200
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