A Temperature-dependent In Silico Model of the Human ether-à-go-go-related (hERG) Gene Channel

INTRODUCTION: Current regulatory guidelines for assessing the risk of QT prolongation include in vitro assays assessing drug effects on the human ether-à-go-go-related (hERG; also known as Kv11.1) channel expressed in cell lines. These assays are typically conducted at room temperature to promote th...

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Bibliografske podrobnosti
izdano v:J Pharmacol Toxicol Methods
Main Authors: Li, Zhihua, Dutta, Sara, Sheng, Jiansong, Tran, Phu N., Wu, Wendy, Colatsky, Thomas
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042861/
https://ncbi.nlm.nih.gov/pubmed/27178106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2016.05.005
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