Improved functional expression of recombinant human ether-a-go-go (hERG) K(+ )channels by cultivation at reduced temperature

BACKGROUND: HERG potassium channel blockade is the major cause for drug-induced long QT syndrome, which sometimes cause cardiac disrhythmias and sudden death. There is a strong interest in the pharmaceutical industry to develop high quality medium to high-throughput assays for detecting compounds wi...

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Detalhes bibliográficos
Main Authors: Chen, Mao Xiang, Sandow, Shaun L, Doceul, Virginie, Chen, Yu Hua, Harper, Heather, Hamilton, Bruce, Meadows, Helen J, Trezise, Derek J, Clare, Jeff J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241608/
https://ncbi.nlm.nih.gov/pubmed/18096051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-7-93
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