Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS). However, the channels can be inhibited by structurally diverse...

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Main Authors: Zhou, Ping-zheng, Babcock, Joseph, Liu, Lian-qing, Li, Min, Gao, Zhao-bing
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085723/
https://ncbi.nlm.nih.gov/pubmed/21623390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.70
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