Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS). However, the channels can be inhibited by structurally diverse...

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Autores principales: Zhou, Ping-zheng, Babcock, Joseph, Liu, Lian-qing, Li, Min, Gao, Zhao-bing
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
Materias:
Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085723/
https://ncbi.nlm.nih.gov/pubmed/21623390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.70
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