Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS). However, the channels can be inhibited by structurally diverse...

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Autors principals: Zhou, Ping-zheng, Babcock, Joseph, Liu, Lian-qing, Li, Min, Gao, Zhao-bing
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085723/
https://ncbi.nlm.nih.gov/pubmed/21623390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.70
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