Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS). However, the channels can be inhibited by structurally diverse...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Ping-zheng, Babcock, Joseph, Liu, Lian-qing, Li, Min, Gao, Zhao-bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085723/
https://ncbi.nlm.nih.gov/pubmed/21623390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.70
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