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A Temperature-dependent In Silico Model of the Human ether-à-go-go-related (hERG) Gene Channel
INTRODUCTION: Current regulatory guidelines for assessing the risk of QT prolongation include in vitro assays assessing drug effects on the human ether-à-go-go-related (hERG; also known as Kv11.1) channel expressed in cell lines. These assays are typically conducted at room temperature to promote th...
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| 出版年: | J Pharmacol Toxicol Methods |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5042861/ https://ncbi.nlm.nih.gov/pubmed/27178106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2016.05.005 |
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