Drug-induced long QT syndrome: hERG K(+) channel block and disruption of protein trafficking by fluoxetine and norfluoxetine

BACKGROUND AND PURPOSE: Fluoxetine (Prozac(®)) is a widely prescribed drug in adults and children, and it has an active metabolite, norfluoxetine, with a prolonged elimination time. Although uncommon, Prozac causes QT interval prolongation and arrhythmias; a patient who took an overdose of Prozac ex...

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Detalhes bibliográficos
Main Authors: Rajamani, S, Eckhardt, L L, Valdivia, C R, Klemens, C A, Gillman, B M, Anderson, C L, Holzem, K M, Delisle, B P, Anson, B D, Makielski, J C, January, C T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014667/
https://ncbi.nlm.nih.gov/pubmed/16967046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706892
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