Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum

KCNH2 encodes Kv11.1 and underlies the rapidly activating delayed rectifier K(+) current (I(Kr)) in the heart. Loss-of-function KCNH2 mutations cause the type 2 long QT syndrome (LQT2), and most LQT2-linked missense mutations inhibit the trafficking of Kv11.1 channels. Drugs that bind to Kv11.1 and...

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Main Authors: Smith, Jennifer L., Reloj, Allison R., Nataraj, Parvathi S., Bartos, Daniel C., Schroder, Elizabeth A., Moss, Arthur J., Ohno, Seiko, Horie, Minoru, Anderson, Corey L., January, Craig T., Delisle, Brian P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042535/
https://ncbi.nlm.nih.gov/pubmed/23864605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00406.2012
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