Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum

KCNH2 encodes Kv11.1 and underlies the rapidly activating delayed rectifier K(+) current (I(Kr)) in the heart. Loss-of-function KCNH2 mutations cause the type 2 long QT syndrome (LQT2), and most LQT2-linked missense mutations inhibit the trafficking of Kv11.1 channels. Drugs that bind to Kv11.1 and...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Smith, Jennifer L., Reloj, Allison R., Nataraj, Parvathi S., Bartos, Daniel C., Schroder, Elizabeth A., Moss, Arthur J., Ohno, Seiko, Horie, Minoru, Anderson, Corey L., January, Craig T., Delisle, Brian P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042535/
https://ncbi.nlm.nih.gov/pubmed/23864605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00406.2012
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky