Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome

BACKGROUND AND PURPOSE: Many drugs associated with acquired long QT syndrome (LQTS) directly block human ether-a-go-go-related gene (hERG) K(+) channels. Recently, disrupted trafficking of the hERG channel protein was proposed as a new mechanism underlying LQTS, but whether this defect coexists with...

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Detalhes bibliográficos
Main Authors: Takemasa, H, Nagatomo, T, Abe, H, Kawakami, K, Igarashi, T, Tsurugi, T, Kabashima, N, Tamura, M, Okazaki, M, Delisle, B P, January, C T, Otsuji, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241789/
https://ncbi.nlm.nih.gov/pubmed/17965736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707537
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