Á lódáil...
Mechanisms of pharmacological rescue of trafficking defective hERG mutant channels in human long QT syndrome
Long QT syndrome type 2 is caused by mutations in the human ether-a-go-go-related gene (hERG). We previously reported that the N470D mutation is retained in the endoplasmic reticulum (ER) but can be rescued to the plasma membrane by hERG channel blocker E-4031. The mechanisms of ER retention and how...
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| Main Authors: | , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2005
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1624912/ https://ncbi.nlm.nih.gov/pubmed/16361248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M511765200 |
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