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Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
Berberine (BBR), an isoquinoline alkaloid mainly isolated from plants of Berberidaceae family, is extensively used to treat gastrointestinal infections in clinics. It has been reported that BBR can block human ether-a-go-go-related gene (hERG) potassium channel and inhibit its membrane expression. T...
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| Veröffentlicht in: | Drug Des Devel Ther |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4622489/ https://ncbi.nlm.nih.gov/pubmed/26543354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S91561 |
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