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Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Berberine (BBR), an isoquinoline alkaloid mainly isolated from plants of Berberidaceae family, is extensively used to treat gastrointestinal infections in clinics. It has been reported that BBR can block human ether-a-go-go-related gene (hERG) potassium channel and inhibit its membrane expression. T...

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Détails bibliographiques
Publié dans:Drug Des Devel Ther
Auteurs principaux: Yan, Meng, Zhang, Kaiping, Shi, Yanhui, Feng, Lifang, Lv, Lin, Li, Baoxin
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622489/
https://ncbi.nlm.nih.gov/pubmed/26543354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S91561
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