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Mechanisms underlying probucol-induced hERG-channel deficiency
The hERG gene encodes the pore-forming α-subunit of the rapidly activating delayed rectifier potassium channel (I(Kr)), which is important for cardiac repolarization. Reduction of I(hERG) due to genetic mutations or drug interferences causes long QT syndrome, leading to life-threatening cardiac arrh...
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| Publicado no: | Drug Des Devel Ther |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516208/ https://ncbi.nlm.nih.gov/pubmed/26229434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S86724 |
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