ロード中...

Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue Potency on Drug-Induced hERG Trafficking Defect

Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. It has been reported that both drugs block the hERG (human ether-a-go-go-related gene) potassium channel which is essential for myocardium repolarization. Abnormality of repolarization increases risk of...

詳細記述

保存先:
書誌詳細
出版年:Int J Mol Sci
主要な著者: Yan, Meng, Fan, Pan, Shi, Yanhui, Feng, Lifang, Wang, Junnan, Zhan, Ge, Li, Baoxin
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085681/
https://ncbi.nlm.nih.gov/pubmed/27690007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17101648
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!