Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells

The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (I(Kr)) and contributes to phase III cardiac action potential repolarization. Drugs inhibit hERG channels by binding to aromatic residues in hERG helixes. Berberine (BBR) has multiple ac...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Yu, Dahai, Lv, Lin, Fang, Li, Zhang, Bo, Wang, Junnan, Zhan, Ge, Zhao, Lei, Zhao, Xin, Li, Baoxin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538702/
https://ncbi.nlm.nih.gov/pubmed/28763460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181823
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge