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Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells
The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (I(Kr)) and contributes to phase III cardiac action potential repolarization. Drugs inhibit hERG channels by binding to aromatic residues in hERG helixes. Berberine (BBR) has multiple ac...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538702/ https://ncbi.nlm.nih.gov/pubmed/28763460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181823 |
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