Mechanisms underlying probucol-induced hERG-channel deficiency

The hERG gene encodes the pore-forming α-subunit of the rapidly activating delayed rectifier potassium channel (I(Kr)), which is important for cardiac repolarization. Reduction of I(hERG) due to genetic mutations or drug interferences causes long QT syndrome, leading to life-threatening cardiac arrh...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Des Devel Ther
Prif Awduron: Shi, Yuan-Qi, Yan, Cai-Chuan, Zhang, Xiao, Yan, Meng, Liu, Li-Rong, Geng, Huai-Ze, Lv, Lin, Li, Bao-Xin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove Medical Press 2015
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516208/
https://ncbi.nlm.nih.gov/pubmed/26229434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S86724
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