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Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro
BACKGROUND: The human ether-a-go-go-related gene (hERG) potassium channel is the rapidly activating component of cardiac delayed rectifier potassium current (I(Kr)), which is a crucial determinant of cardiac repolarization. The reduction of hERG current is commonly believed to cause Long QT Syndrome...
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| Publicado no: | Curr Pharm Des |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Bentham Science Publishers
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7327797/ https://ncbi.nlm.nih.gov/pubmed/31657676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1381612825666191026170033 |
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