Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

Long QT Syndrome (LQTS) is an acquired or inherited disorder characterized by prolonged QT interval, exertion-triggered arrhythmias, and sudden cardiac death. One of the most prevalent hereditary LQTS subtypes, LQT2, results from loss-of-function mutations in the hERG channel, which conducts I(Kr),...

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Vydáno v:Front Physiol
Hlavní autoři: Kanner, Scott A., Jain, Ananya, Colecraft, Henry M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917007/
https://ncbi.nlm.nih.gov/pubmed/29725305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00397
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