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Drug-induced long QT syndrome: hERG K(+) channel block and disruption of protein trafficking by fluoxetine and norfluoxetine
BACKGROUND AND PURPOSE: Fluoxetine (Prozac(®)) is a widely prescribed drug in adults and children, and it has an active metabolite, norfluoxetine, with a prolonged elimination time. Although uncommon, Prozac causes QT interval prolongation and arrhythmias; a patient who took an overdose of Prozac ex...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014667/ https://ncbi.nlm.nih.gov/pubmed/16967046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706892 |
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