Differential modulation of late sodium current by protein kinase A in R1623Q mutant of LQT3

AIMS: In the type 3 long QT syndrome (LQT3), shortening of the QT interval by overdrive pacing is used to prevent life-threatening arrhythmias. However, it is unclear whether accelerated heart rate induced by β-adrenergic agents produces similar effects on the late sodium current (I(Na)) to those by...

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Hauptverfasser: Tsurugi, Takuo, Nagatomo, Toshihisa, Abe, Haruhiko, Oginosawa, Yasushi, Takemasa, Hiroko, Kohno, Ritsuko, Makita, Naomasa, Makielski, Jonathan C., Otsuji, Yutaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747087/
https://ncbi.nlm.nih.gov/pubmed/19167409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2009.01.001
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