Mechanism of hERG K(+) channel blockade by the fluoroquinolone antibiotic moxifloxacin

1. The fluoroquinolone antibiotic moxifloxacin has been associated with the acquired long QT syndrome and is used as a positive control in the evaluation of the QT-interval prolonging potential of new drugs. In common with other QT-prolonging agents, moxifloxacin is known to inhibit the hERG potassi...

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Bibliographic Details
Main Authors: Alexandrou, Ari J, Duncan, Rona S, Sullivan, Anneli, Hancox, Jules C, Leishman, Derek J, Witchel, Harry J, Leaney, Joanne L
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2006
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1760709/
https://ncbi.nlm.nih.gov/pubmed/16474415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706678
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